In my opinion Manchester City is clear favorite of this match and they should be able to win with at least 2 goals margin.

City have really good record against Southampton, they won 7 of last 8 Premier League matches against them (they scored 18 goals in the process). Southampton don't likes to play at Etihad stadium - they lost 8 of 9 matches here.

City coming for today's match with fully fit squad, manager Guardiola don't have any important absences. On the other hand Southampton is without their two key players - central midfielder Romeu (he was heart of their middle zone) and top scorer/team captain Danny Ings. That should have extremely bad impact on their performance today.

I see huge difference between both teams. Southampton recorded only one win in last 9 league matches. They won in last round against Sheffield (last position in table). Anyway, that wasn't convincing performance. Southampton in 2021 is the worst team in whole league - only 7 points with 25 goals conceded. City is the best team in league by far, they had run with 28 matches without a loss and 21 wins in a row. At the weekend they lost in derby of Manchester against United, but that wasn't deserved result - City had 23 shots in that match.. I expect big reaction from the team because they were very disappointed.

City have 64.4% average ball possession in current season and they should control middle zone without any problems, especially when Southampton midfielder Romeu is unavailable . City kept clean sheet 15 times in 28 matches so far and they should be able to do it today once against, especially when Southampton best striker Ings is unavailable. Southampton have one of the worst defense in league (1.6 goals conceded per game) and today City should be able to create a lot of chances to score and for sure with bigger success than against United.

Manchester City won last 17 matches in a row played at Wednesday in Premier League, on the other hand Southampton is without a win in last 22 Premier League away matches played at Wednesday. I expect routine win for hosts.

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在我看来曼城显然是这场比赛中最受欢迎的球队，他们应该能够以至少两球的优势获胜。

曼城在对南安普顿的比赛中取得了很好的成绩，他们在最近的8场英超比赛中赢了7场(他们进了18个球)。南安普顿不喜欢在阿提哈德球场比赛——他们在这里输了9场比赛中的8场。

曼城带着完全康复的阵容来参加今天的比赛，主教练瓜迪奥拉没有任何重要的缺阵。另一方面，南安普顿缺少了他们的两名关键球员——中路中场罗梅乌(他是中路的核心)和顶级射手/队长丹尼·英斯。这应该会对它们今天的表现产生极其糟糕的影响。

我看到了两队之间的巨大差异。南安普顿在最近9场联赛中只有一场胜利。他们在上一轮击败谢菲尔德(积分榜最后一名)。不管怎样，这不是令人信服的表现。2021年的南安普顿是整个联赛中最差的球队——只积7分，丢25球。到目前为止，曼城是联赛中最好的球队，他们已经取得了28场不败，21连胜的战绩。周末曼城在德比中输给了曼联，但那并不是他们应得的结果——曼城在那场比赛中有23次射门。我希望球队会有很大的反应，因为他们非常失望。

曼城在本赛季平均控球率为64.4%，他们应该可以毫无问题地控制中区，尤其是在南安普顿中场罗梅无法上场的情况下。到目前为止，曼城在28场比赛中有15场没有失球，他们应该可以在今天的比赛中做到这一点，尤其是南安普顿最好的前锋缺阵的时候。南安普顿拥有全联盟最差的防守(场均失球1.6个)，今天曼城应该能够创造很多进球机会，而且肯定会比对阵曼联更成功。

曼城在周三英超联赛中连胜17场，而南安普顿在周三英超联赛的22场客场比赛中没有一场胜利。我希望东道主能例行公事地获胜。