There is not much difference in actual table, even loss so in when we look at the performance data xG, so the odds feel generous on Brentford who are better rested, better squad situation and at home!
The xG is always somewhat subjective and there is never an absolute truth, and of course it is based on played matches and not the ones in the future, but they are always worth checking out.
xG- data in the top of EPL looks like this according to one service I have found rather reliable:

Arsenal deservedly lead by 31 expected points, Tottenham have 26, Brentford have 22.
Brentford might even have a full squad available, Tottenham miss for sure several players due injuries and Qatar. Here is the situation on Friday:

At home this season Brentford have lost one game, against Arsenal.
On their travels Tottenham have won 3 games, Nottingham and Bournemouth which is not a big merit, but also Brighton. In that match they were saved by Harry Kane once more, they lost all the other stats but goals.
The long break is a new situation for both teams and for sure there will surprises both now and in the spring months when the Worls cup heroes might start to get tired. In my eyes those teams who had the least players in Qatar will do well now in mid-winter, and Brentford are one of them.
Good luck!
本译文使用有道机器翻译,仅供参考:
在实际的积分榜上没有太大的区别,即使是输球,当我们看表现数据时xG,所以布伦特福德的赔率感觉很慷慨,他们休息得更好,阵容状况更好,在主场!
xG总是有点主观,从来没有绝对的真理,当然它是基于已经进行的比赛,而不是未来的比赛,但它们总是值得检查。
xG- EPL顶部的数据是这样的,根据我发现的一个相当可靠的服务:
阿森纳当之无愧地领先31分,热刺26分,布伦特福德22分。
布伦特福德甚至可能有一个完整的阵容,热刺肯定会错过几名球员,因为伤病和卡塔尔。这是周五的情况:
本赛季布伦特福德在主场输了一场比赛,对手是阿森纳。
在他们的旅途中,热刺赢了3场比赛,赢了诺丁汉和伯恩茅斯,这不是一个很大的优势,还有布莱顿。在那场比赛中,他们又一次被哈里·凯恩扑出,除了进球,他们失去了所有其他数据。
长时间的休息对两支球队来说都是一种新情况,可以肯定的是,无论是现在还是在春季的几个月里,世界杯英雄们可能会开始感到疲惫,都会有惊喜。在我看来,那些在卡塔尔拥有最少球员的球队将在冬季中期表现出色,布伦特福德就是其中之一。
好运!